A putative flip–flop switch for control of REM sleep

@article{Lu2006APF,
  title={A putative flip–flop switch for control of REM sleep},
  author={J. Lu and D. Sherman and M. Devor and C. Saper},
  journal={Nature},
  year={2006},
  volume={441},
  pages={589-594}
}
Rapid eye movement (REM) sleep consists of a dreaming state in which there is activation of the cortical and hippocampal electroencephalogram (EEG), rapid eye movements, and loss of muscle tone. Although REM sleep was discovered more than 50 years ago, the neuronal circuits responsible for switching between REM and non-REM (NREM) sleep remain poorly understood. Here we propose a brainstem flip–flop switch, consisting of mutually inhibitory REM-off and REM-on areas in the mesopontine tegmentum… Expand
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