A putative GDP-GTP exchange factor is required for development of the excretory cell in Caenorhabditis elegans.

@article{Suzuki2001APG,
  title={A putative GDP-GTP exchange factor is required for development of the excretory cell in Caenorhabditis elegans.},
  author={Nobutaka Suzuki and Matthew Buechner and Kiyoji Nishiwaki and David H. Hall and Hideki Nakanishi and Yoshimi Takai and Naoki Hisamoto and Kunihiro Matsumoto},
  journal={EMBO reports},
  year={2001},
  volume={2 6},
  pages={530-5}
}
The Caenorhabditis elegans excretory cell extends tubular processes, called canals, along the basolateral surface of the epidermis. Mutations in the exc-5 gene cause tubulocystic defects in this canal. Ultrastructural analysis suggests that exc-5 is required for the proper placement of cytoskeletal elements at the apical epithelial surface. exc-5 encodes a protein homologous to guanine nucleotide exchange factors and contains motif architecture similar to that of FGD1, which is responsible for… CONTINUE READING

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