A purine-rich sequence in the human BM-40 gene promoter region is a prerequisite for maximum transcription.

@article{Hafner1995APS,
  title={A purine-rich sequence in the human BM-40 gene promoter region is a prerequisite for maximum transcription.},
  author={Martin Hafner and Katrin Zimmermann and J. Pottgiesser and Thomas Krieg and Roswitha Nischt},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={1995},
  volume={14 9},
  pages={733-41}
}
BM-40 (osteonectin, SPARC [secreted protein, acidic, rich in cysteine]) is a highly conserved, matrix-associated protein that is found in basement membranes, bones and remodeling tissues throughout vertebrate evolution. We are reporting the characterization of the 5' end of the human BM-40 gene. Sequence comparison of the 5' region revealed significant homologies with the bovine and murine genes, including a purine-rich stretch composed of two boxes, GGA-box 1 and 2, separated by a pyrimidine… CONTINUE READING

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