A purine antimetabolite attenuates toll-like receptor-2, -4, and subarachnoid hemorrhage-induced brain apoptosis.

@article{Chang2015APA,
  title={A purine antimetabolite attenuates toll-like receptor-2, -4, and subarachnoid hemorrhage-induced brain apoptosis.},
  author={C G Chang and S Wu and A. L. Kwan},
  journal={The Journal of surgical research},
  year={2015},
  volume={199 2},
  pages={676-87}
}
BACKGROUND Upregulation of high-level toll-like receptors (TLRs) is observed in the serum of animals following experimental subarachnoid hemorrhage (SAH) and is highly related to SAH-induced early brain injury (EBI). The present study was of interest to examine the effect of 6-mercaptopurine (6-MP) on alternation of TLR-2, -3, and -4 in this model… CONTINUE READING