A pupillographic evaluation of a phenylephrine HCl 5%-tropicamide 0.8% combination mydriatic.

@article{Kergoat1989APE,
  title={A pupillographic evaluation of a phenylephrine HCl 5\%-tropicamide 0.8\% combination mydriatic.},
  author={H{\'e}l{\`e}ne Kergoat and John V. Lovasik and Michael J. Doughty},
  journal={Journal of ocular pharmacology},
  year={1989},
  volume={5 3},
  pages={
          199-216
        }
}
A continuously recording high-resolution pupillometer was used to measure changes in pupil size and pupil reactivity to temporally modulated light, following topical application of a phenylephrine HCl 5%-tropicamide 0.8% combination mydriatic (Phenyltrope). A controlled light stimulus induced pupillary changes in the left eye while changes in the consensual pupillary responses were measured in the mydriatic-treated right eye. The effects on pupil light reactivity of a single drop of the… 
A combination solution for routine pupillary dilation.
TLDR
Combination preparations of reduced concentrations of tropicamide and phenylephrine can produce clinically adequate mydriasis, and all pupils reached their maximum diameter 60 minutes after drop instillation.
Effective pupil dilatation with a mixture of 0.75% tropicamide and 2.5% phenylephrine: A randomized controlled trial
TLDR
The mixture of 0.75% tropicamide and 2.5% phenylephrine is superior to the standard application of 1% Tropicamide alternating with 10% Phenylephrine and provides faster and more successful pupil dilatation within 40 min.
Effective Pupil Dilatation With A Mixture Of 0.75% Tropicamide And 2.5% Phenylephrine: A Randomized Controlled Trial
TLDR
The mixture of 0.75% tropicamide and 2.5% phenylephrine is superior to the standard application of 1% Tropicamide alternating with 10% Phenylephrine and provides faster and more successful pupil dilatation within 40 min.
Efficacy of topical tropicamide 1% versus a combination of tropicamide 0.8% and phenylephrine 5% for cycloplegia
TLDR
A single drop of a combination of 0.8% Tropicamide and 5% Phenylephrine achieves adequate cycloplegia in patients between 11-40 years of age.
Reversal of tropicamide mydriasis with single instillations of pilocarpine can induce substantial pseudo‐myopia in young adults
TLDR
The results emphasise the need to monitor closely the potential pseudo-myopic effects of pilocarpine, especially in light coloured irides where an adequate standard of vision for driving might be at risk and reinstatement of an easily accessible formulation of thymoxamine (or dapiprazole HCl) should be encouraged.
Single dose of 1% tropicamide and 10% phenylephrine for pupil dilation.
TLDR
The single dose of 1% tropicamide and 10% phenylephrine was clinically equivalent to the three doses of the same drugs and the 95% confidence interval of the difference in pupil size lay entirely within the range of equivalence.
Sympathetic influence on the pupillary light response in three red-eared slider turtles (Trachemys scripta elegans).
TLDR
The results suggest that sympathetic innervation interacts with the parasympathetic pathway to control the pupillary light response in turtles.
Comparative studies on mydriatic effect of tropicamide 0.8% and phenylephrin 5.0% in teenagers & geriatric people
TLDR
There is a large difference in the normal pupil size between teenagers and geriatric people and the pupillary dilation produced by administering 0.8% Tropicamide and 5% Phenylephrine produces higher mydriatic effect in teenagers than Geriatric people.
The effects of two systemic α1-adrenergic blockers on pupil diameter: a prospective randomized single-blind study
TLDR
Compared to baseline values, small but statistically significant decreases were detected in mesopic and scotopic illumination in patients treated with tamsulosin and inScotopic PD in patients treating with alfuzosin.
The effects of altered retinal vascular perfusion pressure on the white flash scotopic ERG and oscillatory potentials in man.
TLDR
The study has isolated a component-specific vulnerability to altered retinal perfusion, and the heightened sensitivity of OP-5 to alteration of the RVPP may offer diagnostic advantage for investigating chronic diseases causing retinal ischemia.
...
1
2
...

References

SHOWING 1-7 OF 7 REFERENCES
Evaluation of drugs in ointment for mydriasis and cycloplegia.
TLDR
Ointment preparations of cyclopentolate hydrochloride and tropicamide were compared with aqueous drops of these medications for the production of mydriasis and/or cycloplegia in clinic patients and ocular irritation was minimal, and there was no interference with subsequent ocular examination.
Mydriatic Effect of Low Dose Phenylephrine
TLDR
The mydriatic effect of one drop (40 μl) of 2.5 and 10% phenylephrine was studied in human eyes and registered by a measuring eye- diameter.
MYDRIATICS AND AGE
TLDR
Comparison of mydriasis obtained with different mydriatics in young and in old people may be of interest, both from a practical point of view, and because this comparison may elucidate age changes of iris from a physiological points of view.
Polymer effects on ocular bioavailability. II. The influence of benzalkonium chloride on the mydriatic response of tropicamide in different polymeric vehicles
The effect of 0.01% benzalkonium chloride (BZ) on the mydriatic response of tropicamide in different vehicles was tested on rabbits and on humans. The vehicles were an isotonic buffered solution (AS)
Cycloplegics and mydriatics. Tolerance, habituation, and addiction to topical administration.
A patient had tolerance, habituation, and addiction to the topical use of a combination of cyclopentolate hydrochloride and tropicamide. He also developed a blotchy, diffuse epithelial keratitis that
Ageing and alpha1 adrenoceptors in the iris
TLDR
Log dose response curves using the selective alpha1 agonist phenylephrine and antagonist thymoxamine showed that there is no difference in alpha1 adrenoceptor sensitivity in the elderly and the young, indicating that age related miosis is not caused by an alteration inalpha1 receptors with age.