A psychopharmacological study to assess anti‐muscarinic and central nervous effects of medifoxamine in normal volunteers

  title={A psychopharmacological study to assess anti‐muscarinic and central nervous effects of medifoxamine in normal volunteers},
  author={Mohammad Akram Randhawa and Alan Hedges and Atholl Johnston and Pauline Turner},
  journal={Human Psychopharmacology: Clinical and Experimental},
Ten volunteers received single oral doses of medifoxamine 50 and 100 mg, atropine 1 mg, amitriptyline 50 mg or placebo in random order based on a Latin square design under double‐blind conditions. Tests of anti‐muscarinic and central nervous activity were carried out at hourly intervals for 6 hours. The tests were measurements of salivary volume, heart rate, pupil diameter, manual dexterity, choice reaction time, critical flicker frequency, and visual analogue rating scales for sedation… 

The pharmacokinetics and pharmacodynamics of medifoxamine after oral administration in healthy elderly volunteers

The pharmacokinetics and psychomotor effects of medifoxamine, a 5 HT reuptake inhibitory antidepressant, were studied in healthy elderly volunteers after single and multiple dosing to find no significant changes in critical flicker fusion frequency, symbol digit substitution, continuous attention or choice reaction times.

Absolute bioavailability and pharmacokinetics of medifoxamine in healthy humans.

A biexponential decline of serum medifoxamine concentration was observed after intravenous administration in all subjects and similar terminal elimination half-lives were observed following both routes, indicating that oral absorption is not rate-limiting.

Medifoxamine: Oral tolerance and pharmacokinetic study in healthy human volunteers

It was found that medifoxamine underwent rapid absorption and peak plasma concentrations were achieved about 1.0 h after administration, and the elimination profile was biphasic with a mean terminal half life less than 3 hours.

Human psychopharmacology of second generation antidepressants.

Data presented in this thesis suggest that there are differences in the extent to which these drugs affect performance, which should be taken into consideration in the management of depression in ambulant outpatients.

Biochemical evidence for the involvement of central serotonergic neurotransmission in the action of the antidepressant drug Medifoxamine

Results indicate that medifoxamine, which has been shown previously to act through dopaminergic systems, interacts also with central serotonergic neurotransmission and particularly with the 5‐HT2 receptors, which could contribute to its antidepressant effect.

Ocular hypotensive effects of medifoxamine.

In human volunteer studies, Medifoxamine has been found to reduce significantly intraocular pressure after single oral doses of 300-1000 mg, and to produce a small but statistically significant miosis.

New Statistical Proposals to Evaluate the Benefit/Risk Ratio of Long-Term Treatment of Depression

Its benefit/risk ratio appeared to be superior to fluoxetine, but this difference was mainly based on the occurrence of less minor adverse effects, a potential advantage not sufficient to favour better compliance with long-term therapy.



Evaluation of possible interactions between ethanol and trazodone or amitriptyline.

Ethanol alone impaired manual dexterity, increased drowsiness, reduced 'clearheadedness' and also tended to reduce feelings of aggression and in combination with either trazodone or amitriptyline, ethanol caused little additional effect, which may reflect the profound effects of the antidepressants alone.

Psychomotor function and psychoactive drugs.

  • I. Hindmarch
  • Psychology
    British journal of clinical pharmacology
  • 1980
A cursory review of the literature reveals that the techniques used to assess psychomotor functions are diverse, often complex, frequently insensitive to drug induced changes and sometimes