A psychopharmacological study to assess anti‐muscarinic and central nervous effects of medifoxamine in normal volunteers

@article{Randhawa1988APS,
  title={A psychopharmacological study to assess anti‐muscarinic and central nervous effects of medifoxamine in normal volunteers},
  author={Mohammad Akram Randhawa and Alan Hedges and Atholl Johnston and Pauline Turner},
  journal={Human Psychopharmacology: Clinical and Experimental},
  year={1988},
  volume={3}
}
Ten volunteers received single oral doses of medifoxamine 50 and 100 mg, atropine 1 mg, amitriptyline 50 mg or placebo in random order based on a Latin square design under double‐blind conditions. Tests of anti‐muscarinic and central nervous activity were carried out at hourly intervals for 6 hours. The tests were measurements of salivary volume, heart rate, pupil diameter, manual dexterity, choice reaction time, critical flicker frequency, and visual analogue rating scales for sedation… 

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It was found that medifoxamine underwent rapid absorption and peak plasma concentrations were achieved about 1.0 h after administration, and the elimination profile was biphasic with a mean terminal half life less than 3 hours.

Human psychopharmacology of second generation antidepressants.

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Results indicate that medifoxamine, which has been shown previously to act through dopaminergic systems, interacts also with central serotonergic neurotransmission and particularly with the 5‐HT2 receptors, which could contribute to its antidepressant effect.

Ocular hypotensive effects of medifoxamine.

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A cursory review of the literature reveals that the techniques used to assess psychomotor functions are diverse, often complex, frequently insensitive to drug induced changes and sometimes