A pseudotype vesicular stomatitis virus containing Hantaan virus envelope glycoproteins G1 and G2 as an alternative to hantavirus vaccine in mice.

@article{Lee2006APV,
  title={A pseudotype vesicular stomatitis virus containing Hantaan virus envelope glycoproteins G1 and G2 as an alternative to hantavirus vaccine in mice.},
  author={Byoung-Hee Lee and Kumiko Yoshimatsu and Koichi Araki and Megumi J. Okumura and Ichiro Nakamura and Jiro Arikawa},
  journal={Vaccine},
  year={2006},
  volume={24 15},
  pages={
          2928-34
        }
}
  • Byoung-Hee Lee, Kumiko Yoshimatsu, +3 authors Jiro Arikawa
  • Published in Vaccine 2006
  • Biology, Medicine
  • We examined whether a vesicular stomatitis virus (VSV) pseudotype bearing the hantavirus envelope glycoproteins (GPs) G1 and G2 (VSVdeltaG*HTN) could be used as a safe and effective alternative to native hantavirus. Mice were immunized with purified particles of VSVdeltaG*HTN. After the second immunization, all mice produced anti-GP antibody as detected in ELISA and a neutralization test. After the third immunization, the mice were challenged with Hantaan virus. Neither anti-NP antibody… CONTINUE READING

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