A pseudoknot-like structure required for efficient self-cleavage of hepatitis delta virus RNA

HEPATITIS delta virus genomic and antigenomic RNAs contain a self-cleavage site hypothesized to function in processing the viral RNA during replication1–3. Self-cleavage requires only a divalent cation1–3 and is mediated at the genomic site by a sequence of less than 85 nucleotides4. We propose that the genomic self-cleaving sequence element4 and a… CONTINUE READING