A proton gradient is the driving force for uphill transport of lactate in human placental brush-border membrane vesicles.

@article{Balkovetz1988APG,
  title={A proton gradient is the driving force for uphill transport of lactate in human placental brush-border membrane vesicles.},
  author={Daniel F Balkovetz and Fredrich H. Leibach and Virendra B. Mahesh and Vadivel Ganapathy},
  journal={The Journal of biological chemistry},
  year={1988},
  volume={263 27},
  pages={13823-30}
}
The characteristics of lactate transport in brush-border membrane vesicles isolated from normal human full-term placentas were investigated. Lactate transport in these vesicles was Na+-independent, but was greatly stimulated when the extravesicular pH was made acidic. In the presence of an inwardly directed H+ gradient ([H+]o greater than [H+]i), transient uphill transport of lactate could be demonstrated. This H+ gradient-dependent stimulation was not a result of a H+ diffusion potential… CONTINUE READING
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