A protocol for exosome isolation and characterization: evaluation of ultracentrifugation, density-gradient separation, and immunoaffinity capture methods.

@article{Greening2015APF,
  title={A protocol for exosome isolation and characterization: evaluation of ultracentrifugation, density-gradient separation, and immunoaffinity capture methods.},
  author={David W. Greening and Rong Xu and Hong Tai Ji and Bow J Tauro and Richard J. Simpson},
  journal={Methods in molecular biology},
  year={2015},
  volume={1295},
  pages={179-209}
}
Exosomes are 40-150 nm extracellular vesicles that are released from a multitude of cell types, and perform diverse cellular functions including intercellular communication, antigen presentation, and transfer of tumorigenic proteins, mRNA and miRNA. Exosomes are important regulators of the cellular niche, and their altered characteristics in many diseases, such as cancer, suggest their importance for diagnostic and therapeutic applications, and as drug delivery vehicles. Exosomes have been… CONTINUE READING
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