A proteomics platform combining depletion, multi-lectin affinity chromatography (M-LAC), and isoelectric focusing to study the breast cancer proteome.

@article{Zeng2011APP,
  title={A proteomics platform combining depletion, multi-lectin affinity chromatography (M-LAC), and isoelectric focusing to study the breast cancer proteome.},
  author={Zhi Zeng and Marina Hincapie and Sharon J Pitteri and Samir M Hanash and Joost Schalkwijk and Jason M. Hogan and Hong Wang and William S. Hancock},
  journal={Analytical chemistry},
  year={2011},
  volume={83 12},
  pages={4845-54}
}
The discovery of breast cancer associated plasma/serum biomarkers is important for early diagnosis, disease mechanism elucidation, and determination of treatment strategy for the disease. In this study of serum samples, a multidimensional fractionation platform combined with mass spectrometric analysis were used to achieve the identification of medium to lower abundance proteins, as well as to simultaneously detect glycan and abundance changes. Immuno-affinity depletion and multi-lectin… CONTINUE READING

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Proteomics 

G. Zilberstein, L. Korol, S. Bukshpan, E. Baskin
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