A proteomic approach to cisplatin resistance in the cervix squamous cell carcinoma cell line A431.

@article{Castagna2004APA,
  title={A proteomic approach to cisplatin resistance in the cervix squamous cell carcinoma cell line A431.},
  author={Annalisa Castagna and Paolo Antonioli and Hubert Astner and Mahmoud Hamdan and Sabina Carla Righetti and Paola Perego and Franco Zunino and Pier Giorgio Righetti},
  journal={Proteomics},
  year={2004},
  volume={4 10},
  pages={3246-67}
}
Since drug resistance is a complex and multifactorial event involving activation/repression of multiple biochemical pathways, we used a proteomic approach to study cisplatin resistance and drug response in human tumor cell lines. The cervix squamous cell carcinoma cell line A431 and its cisplatin-resistant subline, A431/Pt, were used as a model system. The experimental set-up involved not just a two-way comparison of the control vs. the drug-resistant cell line, but also an acute cisplatin… CONTINUE READING