A proteomic approach identifies proteins in hepatocytes that bind nascent apolipoprotein B.

@article{Rashid2002APA,
  title={A proteomic approach identifies proteins in hepatocytes that bind nascent apolipoprotein B.},
  author={Khwaja Aftab Rashid and Sarah Hevi and Yin Yuan Chen and Françoise Le Cah{\'e}rec and Steven L. Chuck},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 24},
  pages={
          22010-7
        }
}
The biogenesis of apolipoprotein B is quite complex in view of its huge size, hydrophobicity, obligate association with lipids such as cholesterol and triglycerides prior to secretion, and intracellular degradation of a substantial proportion of newly synthesized molecules. Multiple proteins likely serve roles as molecular chaperones to assist in folding, assembly with lipids, and regulation of the secretion of apolipoprotein B. In these studies, we developed a strategy to isolate proteins… CONTINUE READING
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