A proteomic approach for plasma biomarker discovery with 8-plex iTRAQ labeling and SCX-LC-MS/MS

@article{Ye2010APA,
  title={A proteomic approach for plasma biomarker discovery with 8-plex iTRAQ labeling and SCX-LC-MS/MS},
  author={Haige Ye and Li Sun and Xiaojun Huang and Ping Zhang and Xiaoshu Zhao},
  journal={Molecular and Cellular Biochemistry},
  year={2010},
  volume={343},
  pages={91-99}
}
Plasma is recognized as a promising source of disease-related biomarkers, and proteomic approaches for identifying novel plasma biomarkers are in great demand. However, the complexity and dynamic protein concentration range of plasma remain the main obstacles for current research in this field. In this study, plasma proteins were prefractioned by immunodepletion and Protein Equalizer Technology to remove high abundant proteins, then labeled with an 8-plex isobaric tags for relative and absolute… CONTINUE READING
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