A proteomic and transcriptional view of acidogenic and solventogenic steady-state cells of Clostridium acetobutylicum in a chemostat culture

@inproceedings{Janssen2010APA,
  title={A proteomic and transcriptional view of acidogenic and solventogenic steady-state cells of Clostridium acetobutylicum in a chemostat culture},
  author={Holger Janssen and Christina D{\"o}ring and Armin Ehrenreich and Birgit Voigt and Michael Hecker and Hubert Bahl and Ralf-J{\"o}rg Fischer},
  booktitle={Applied Microbiology and Biotechnology},
  year={2010}
}
The complex changes in the life cycle of Clostridium acetobutylicum, a promising biofuel producer, are not well understood. During exponential growth, sugars are fermented to acetate and butyrate, and in the transition phase, the metabolism switches to the production of the solvents acetone and butanol accompanied by the initiation of endospore formation. Using phosphate-limited chemostat cultures at pH 5.7, C. acetobutylicum was kept at a steady state of acidogenic metabolism, whereas at pH 4… CONTINUE READING