A proteomic analysis of lysosomal integral membrane proteins reveals the diverse composition of the organelle.

@article{Bagshaw2005APA,
  title={A proteomic analysis of lysosomal integral membrane proteins reveals the diverse composition of the organelle.},
  author={Richard D. Bagshaw and Don Joseph Mahuran and John William Callahan},
  journal={Molecular & cellular proteomics : MCP},
  year={2005},
  volume={4 2},
  pages={133-43}
}
Lysosomes are endocytic subcellular compartments that contribute to the degradation and recycling of cellular material. Using highly purified rat liver tritosomes (Triton WR1339-filled lysosomes) and an ion exchange chromatography/LC-tandem MS-based protein/peptide separation and identification procedure, we characterized the major integral membrane protein complement of this organelle. While many of the 215 proteins we identified have been previously associated with lysosomes and endosomes… CONTINUE READING

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