A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.

@article{Mu2007APA,
  title={A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.},
  author={J J Mu and Yi Ke Wang and Hao Luo and Mei Chen Leng and Jinglan Zhang and Tao Yang and Dario Besusso and Sung Yun Jung and Jun Qin},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 24},
  pages={17330-4}
}
ATM (ataxia telangiectasia-mutated) and ATR (ATM-Rad3-related) are proximal checkpoint kinases that regulate DNA damage response (DDR). Identification and characterization of ATM/ATR substrates hold the keys for the understanding of DDR. Few techniques are available to identify protein kinase substrates. Here, we screened for potential ATM/ATR substrates using phospho-specific antibodies against known ATM/ATR substrates. We identified proteins cross-reacting to phospho-specific antibodies in… CONTINUE READING