A proteomic analysis of arsenical drug resistance in Trypanosoma brucei

  title={A proteomic analysis of arsenical drug resistance in Trypanosoma brucei},
  author={A. Foucher and A. Mcintosh and G. Douce and J. Wastling and A. Tait and C. M. Turner},
  • A. Foucher, A. Mcintosh, +3 authors C. M. Turner
  • Published 2006
  • Biology, Medicine
  • We have undertaken 2‐DE and MS to identify proteins associated with arsenical drug resistance in Trypanosoma brucei. This parasite causes sleeping sickness in humans, and arsenical drug resistance is a significant potential problem. Comparative analysis of approximately 2000 spots resolved by 2‐DE in the soluble proteomes of drug‐sensitive and drug‐resistant isogenic lines of T. brucei identified a protein spot whose absence associated with resistance to the arsenical drug, Cymelarsan. MS… CONTINUE READING
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