A proteome analysis of the arsenite response in cultured lung cells: evidence for in vitro oxidative stress-induced apoptosis.

@article{Lau2004APA,
  title={A proteome analysis of the arsenite response in cultured lung cells: evidence for in vitro oxidative stress-induced apoptosis.},
  author={Andy T Y Lau and Qing-Yu He and Jen-fu Chiu},
  journal={The Biochemical journal},
  year={2004},
  volume={382 Pt 2},
  pages={641-50}
}
Arsenite is well documented as a chemotherapeutic agent capable of inducing cell death. However, the cellular response at the molecular level has not been studied extensively. In the present study, we provide for the first time a proteomic analysis of rat LECs (lung epithelial cells) treated with arsenite, with the aim of identifying defence proteins, probably expressed to protect the cells during the course of arsenic-induced apoptosis. Comparative proteome analysis was conducted on LECs and… CONTINUE READING
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