A protein transduction domain with cell uptake and selectivity profiles that are controlled by multivalency effects.

@article{DePorter2013APT,
  title={A protein transduction domain with cell uptake and selectivity profiles that are controlled by multivalency effects.},
  author={Sandra M. DePorter and Irene Lui and Utpal Mohan and Brian R McNaughton},
  journal={Chemistry & biology},
  year={2013},
  volume={20 3},
  pages={434-44}
}
Protein transduction domains (PTDs) are reagents that facilitate the delivery of diverse cargo to the interior of mammalian cells. We identified a PTD called "Ypep" (N-YTFGLKTSFNVQ-C), with cell penetration selectivity and potency profiles that are tightly controlled by multivalency effects. Pentavalent display of Ypep on M13 bacteriophage enables selective uptake of this phage in PC-3 human prostate cancer cells at low picomolar concentration and in the presence of human blood. All Ypep… CONTINUE READING