A protein secretion system linked to bacteroidete gliding motility and pathogenesis.

  title={A protein secretion system linked to bacteroidete gliding motility and pathogenesis.},
  author={Keiko Sato and Mariko Fujimoto Naito and Hideharu Yukitake and Hideki Hirakawa and M Shoji and Mark J McBride and Ryan G. Rhodes and Koji Nakayama},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 1},
Porphyromonas gingivalis secretes strong proteases called gingipains that are implicated in periodontal pathogenesis. Protein secretion systems common to other Gram-negative bacteria are lacking in P. gingivalis, but several proteins, including PorT, have been linked to gingipain secretion. Comparative genome analysis and genetic experiments revealed 11 additional proteins involved in gingipain secretion. Six of these (PorK, PorL, PorM, PorN, PorW, and Sov) were similar in sequence to… CONTINUE READING
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