A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

@article{Mishra2017APP,
  title={A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis},
  author={Ajay Mishra and Angela Oliveira Pisco and B{\'e}n{\'e}dicte Oul{\`e}s and Tony Ly and Kifayathullah Liakath-Ali and Gernot Walko and Priyalakshmi Viswanathan and Jagdeesh Nijjhar and Sara-Jane Dunn and Angus I. Lamond and Fiona M. Watt},
  journal={eLife},
  year={2017},
  volume={6}
}
Epidermal homeostasis depends on a balance between stem cell renewal and terminal differentiation. The transition between the two cell states, termed commitment, is poorly understood. Here we characterise commitment by integrating transcriptomic and proteomic data from disaggregated primary human keratinocytes held in suspension for up to 12h to induce differentiation. We find that cell detachment induces a network of protein phosphatases. The pro-commitment phosphatases – including DUSP6… 
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