A protein kinase network regulates the function of aminophospholipid flippases.

@article{Roelants2010APK,
  title={A protein kinase network regulates the function of aminophospholipid flippases.},
  author={Françoise M. Roelants and Alexander G Baltz and Amy E. Trott and Sol Fereres and J. Thorner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 1},
  pages={34-9}
}
Limited exposure of aminophospholipids on the outer leaflet of the plasma membrane is a fundamental feature of eukaryotic cells and is maintained by the action of inward-directed P-type ATPases ("flippases"). Yeast S. cerevisiae has five flippases (Dnf1, Dnf2, Dnf3, Drs2, and Neo1), but their regulation is poorly understood. Two paralogous plasma membrane-associated protein kinases, Pkh1 and Pkh2 (orthologs of mammalian PDK1), are required for viability of S. cerevisiae cells because they… CONTINUE READING
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