A protein kinase inhibitor gene reduces both basal and multihormone-stimulated prolactin gene transcription.

@article{Day1989APK,
  title={A protein kinase inhibitor gene reduces both basal and multihormone-stimulated prolactin gene transcription.},
  author={Richard N. Day and Joseph A Walder and Richard A. Maurer},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 1},
  pages={431-6}
}
The possible role of the catalytic subunit of the cAMP-dependent protein kinase in mediating the regulation of prolactin gene transcription has been investigated through the use of a synthetic gene encoding the heat-stable inhibitor of the cAMP-dependent protein kinase. To assess the effects of protein kinase inhibitor expression on cAMP induction of prolactin gene transcription, a marker gene containing the rat prolactin promoter and adjacent 5'-flanking sequences linked to the bacterial… CONTINUE READING
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