A protein kinase G-sensitive channel mediates flow-induced Ca(2+) entry into vascular endothelial cells.

@article{Yao2000APK,
  title={A protein kinase G-sensitive channel mediates flow-induced Ca(2+) entry into vascular endothelial cells.},
  author={Xiao-qiang Yao and H Y Kwan and Franky Leung Chan and N W K Chan and Y Huang},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2000},
  volume={14 7},
  pages={932-8}
}
The hemodynamic force generated by blood flow is considered to be the physiologically most important stimulus for the release of nitric oxide (NO) and prostacyclin (PGI(2)) from vascular endothelial cells (1). NO and PGI(2) then act on the underlying smooth muscle cells, causing vasodilation and thus lowering blood pressure (2, 3). One critical early event occurring in this flow-induced regulation of vascular tone is that blood flow induces Ca(2+) entry into vascular endothelial cells, which in… CONTINUE READING

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