A protein kinase A–dependent molecular switch in synapsins regulates neurite outgrowth

  title={A protein kinase A–dependent molecular switch in synapsins regulates neurite outgrowth},
  author={H. M. Kao and Hong-jun Song and Barbara Porton and Guoli Ming and Josephine Hoh and Michael Abraham and Andrew J. Czernik and Vincent A. Pieribone and Mu-Ming Poo and Paul Greengard},
  journal={Nature Neuroscience},
Cyclic AMP (cAMP) promotes neurite outgrowth in a variety of neuronal cell lines through the activation of protein kinase A (PKA). We show here, using both Xenopus laevis embryonic neuronal culture and intact X. laevis embryos, that the nerve growth–promoting action of cAMP/PKA is mediated in part by the phosphorylation of synapsins at a single amino acid residue. Expression of a mutated form of synapsin that prevents phosphorylation at this site, or introduction of phospho-specific antibodies… CONTINUE READING
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