A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes.

@article{Passmore1989API,
  title={A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes.},
  author={S E Passmore and R. Elble and Bik K. Tye},
  journal={Genes & development},
  year={1989},
  volume={3 7},
  pages={921-35}
}
The Saccharomyces cerevisiae MCM1 gene product is a protein with multiple functions. It is a transcription factor necessary for expression of mating-type-specific genes and is also required for the maintenance of minichromosomes. MCM1 shows DNA-binding specificities similar to those of two previously reported DNA-binding factors, pheromone/receptor transcription factor (PRTF) and general regulator of mating type (GRM); like PRTF, its activity can be modulated by the alpha 1 protein. MCM1 binds… CONTINUE READING

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dna bindingProcess involves geneSRF wt Allele
Direct and indirect DNA binding assays suggest that a conserved 5'-ATTAGG in one - half of the dyad symmetry element is important for MCM1 binding whereas variants in the other half are tolerated .
MCM1 contains striking homology to the DNA - binding domain of the human serum response factor ( SRF ) which mediates the transient transcriptional activation of growth - stimulated genes by binding to the serum response element ( SRE ) .
MCM1 contains striking homology to the DNA - binding domain of the human serum response factor ( SRF ) which mediates the transient transcriptional activation of growth - stimulated genes by binding to the serum response element ( SRE ) .
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