A protein interaction map of Drosophila melanogaster.

@article{Giot2003API,
  title={A protein interaction map of Drosophila melanogaster.},
  author={Loic Giot and Joel S. Bader and Cory Brouwer and Avi Chaudhuri and Bing Kuang and Yi Li and Yulin Hao and Chean Eng Ooi and Brian Christopher Godwin and Egils Vītols and Govindan Vijayadamodar and Ph. Pochart and H Machineni and Mark K Welsh and Ying Kong and Bryan D. Zerhusen and Robert Dingwall Malcolm and Z Varrone and Amanda J. Collis and Michael Minto and Steven Burgess and Lee McDaniel and Eric Stimpson and Franklin P. Spriggs and John I. Williams and K Neurath and Noelle Ioime and Mark D. Agee and Egbert Voss and Krystyna J. Furtak and Roberta Renzulli and N Aanensen and S Carrolla and E Bickelhaupt and Y Lazovatsky and Anicet O. Dasilva and Jingping Zhong and Clement A. Stanyon and Russell L. Finley and Kevin P. White and Mark Braverman and Thomas P. Jarvie and Scott D. Gold and Meganne E. Leach and Jennifer J Knight and Richard A. Shimkets and Michael Mckenna and John F. Chant and Jonathan Marc Rothberg},
  journal={Science},
  year={2003},
  volume={302 5651},
  pages={
          1727-36
        }
}
Drosophila melanogaster is a proven model system for many aspects of human biology. Here we present a two-hybrid-based protein-interaction map of the fly proteome. A total of 10,623 predicted transcripts were isolated and screened against standard and normalized complementary DNA libraries to produce a draft map of 7048 proteins and 20,405 interactions. A computational method of rating two-hybrid interaction confidence was developed to refine this draft map to a higher confidence map of 4679… CONTINUE READING

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