A protein from polymorphonuclear leukocytes (LEM) which affects the rate of hepatic amino acid transport and synthesis of acute-phase globulins.

@article{Wannemacher1975APF,
  title={A protein from polymorphonuclear leukocytes (LEM) which affects the rate of hepatic amino acid transport and synthesis of acute-phase globulins.},
  author={R. Wannemacher and R. Pekarek and W. Thompson and R. Curnow and F. Beall and T. Zenser and F. DeRubertis and W. Beisel},
  journal={Endocrinology},
  year={1975},
  volume={96 3},
  pages={
          651-61
        }
}
A proteinaceous secretion from phagocytizing polymorphonuclear leukocytes, termed "leukocytic endogenous mediator" (LEM), has been shown to have marked effects on hepatic amino acid transport and RNA and protein synthesis. A single injection of LEM results in a marked accumulation of labeled nonmetabolizable model amino acids in the liver of normal rats. The LEM-stimulated uptake of amino acids by liver was observed in adrenalectomized, hypophysectomized, thyroidectomized, or diabetic rats and… Expand
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  • Biology, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
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Leukocyte endogenous mediator alters protein dynamics in rats.
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