A protein from a parasitic microorganism, Rickettsia prowazekii, can cleave the signal sequences of proteins targeting mitochondria.

@article{Kitada2007APF,
  title={A protein from a parasitic microorganism, Rickettsia prowazekii, can cleave the signal sequences of proteins targeting mitochondria.},
  author={Sakae Kitada and Tsuneo Uchiyama and Tomoyuki Funatsu and Yumiko Kitada and Tadashi Ogishima and Akio Ito},
  journal={Journal of bacteriology},
  year={2007},
  volume={189 3},
  pages={
          844-50
        }
}
The obligate intracellular parasitic bacteria rickettsiae are more closely related to mitochondria than any other microbes investigated to date. A rickettsial putative peptidase (RPP) was found to resemble the alpha and beta subunits of mitochondrial processing peptidase (MPP), which cleaves the transport signal sequences of mitochondrial preproteins. RPP showed completely conserved zinc-binding and catalytic residues compared with beta-MPP but barely contained any of the glycine-rich loop… CONTINUE READING

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