A protein complex in the brush-border membrane explains a Hartnup disorder allele.

@article{Kowalczuk2008APC,
  title={A protein complex in the brush-border membrane explains a Hartnup disorder allele.},
  author={Sonja Kowalczuk and Angelika Br{\"o}er and Nadine Tietze and Jessica May Vanslambrouck and John E J Rasko and Stefan Br{\"o}er},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2008},
  volume={22 8},
  pages={2880-7}
}
Protein absorption in the intestine is mediated by proteases and brush-border peptidases together with peptide and amino acid transporters. Neutral amino acids are generated by a variety of aminopeptidases and carboxypeptidases and are subsequently taken up by the amino acid transporter B(0)AT1 (SLC6A19), which is mutated in Hartnup disorder. Coexpression of B(0)AT1 together with the brush-border carboxypeptidase angiotensin-converting enzyme 2 (ACE2) in Xenopus laevis oocytes led to a dramatic… CONTINUE READING