A protein's conformational stability is an immunologically dominant factor: evidence that free-energy barriers for protein unfolding limit the immunogenicity of foreign proteins.

@article{Ohkuri2010APC,
  title={A protein's conformational stability is an immunologically dominant factor: evidence that free-energy barriers for protein unfolding limit the immunogenicity of foreign proteins.},
  author={Takatoshi Ohkuri and Satoko Nagatomo and Kenji Oda and Takanori So and Taiji Imoto and Tadashi Ueda},
  journal={Journal of immunology},
  year={2010},
  volume={185 7},
  pages={4199-205}
}
Foreign protein Ags are incorporated into APCs and then degraded by endosomal proteases. The peptides are then mounted on MHC II molecules on the surfaces of APCs. The T cell-triggering response and, therefore, the immune response, were suggested to be governed by the degree of conformational stability of the foreign protein Ags. However, there is little… CONTINUE READING