A protective role for testosterone in adjuvant-induced arthritis.

  title={A protective role for testosterone in adjuvant-induced arthritis.},
  author={Michael S. Harbuz and Z Perveen-Gill and Stafford L. Lightman and David S. Jessop},
  journal={British journal of rheumatology},
  volume={34 12},
We have investigated the role of the gonadal steroids testosterone (T) and progesterone in modulating: (1) the onset and severity of adjuvant-induced arthritis (AA), (2) the response of the hypothalamo-pituitary-adrenal (HPA) axis, and (3) the levels of plasma prolactin and anterior pituitary prolactin messenger ribonucleic acid (mRNA) in the rat. Male rats were castrated (CSX) and received either no T, low T or high T delivered using silastic implants. In a second study experimental groups… CONTINUE READING
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