A protective role for lipid raft cholesterol against amyloid-induced membrane damage in human neuroblastoma cells.

  title={A protective role for lipid raft cholesterol against amyloid-induced membrane damage in human neuroblastoma cells.},
  author={Cristina Cecchi and Daniela Nichino and Mariagioia Zampagni and Caterina Bernacchioni and Elisa Evangelisti and Anna Pensalfini and Gianfranco Liguri and Alessandra Gliozzi and Massimo Stefani and Annalisa Relini},
  journal={Biochimica et biophysica acta},
  volume={1788 10},
Increasing evidence supports the idea that the initial events of Abeta oligomerization and cytotoxicity in Alzheimer's disease involve the interaction of amyloid Abeta-derived diffusible ligands (ADDLs) with the cell membrane. This also indicates lipid rafts, ordered membrane microdomains enriched in cholesterol, sphingolipids and gangliosides, as likely primary interaction sites of ADDLs. To shed further light on the relation between ADDL-cell membrane interaction and oligomer cytotoxicity, we… CONTINUE READING


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