A protective role for IL-6 in staphylococcal microbial keratitis.

  title={A protective role for IL-6 in staphylococcal microbial keratitis.},
  author={Emma B. H. Hume and Nerida Cole and Linda L Garthwaite and Shamila Khan and Mark Willcox},
  journal={Investigative ophthalmology & visual science},
  volume={47 11},
PURPOSE To determine whether interleukin-6 (IL-6) plays a protective role in Staphylococcus aureus keratitis in a gene knockout (gko) mouse model and to determine whether IL-6 may be used as a therapy to modulate host responses and control bacterial infection, thereby reducing scarring. METHODS The eyes of IL-6 gko mice and wild-type mice were challenged topically with S. aureus and examined at 24 hours after infection. Keratitis was examined clinically and histologically. Bacterial and… CONTINUE READING


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