A protective protein antigen of Rickettsia rickettsii has tandemly repeated, near-identical sequences.

@article{Anderson1990APP,
  title={A protective protein antigen of Rickettsia rickettsii has tandemly repeated, near-identical sequences.},
  author={Byron Anderson and G. S. A. Mcdonald and Don Carl Jones and Russell Lawrence Regnery},
  journal={Infection and immunity},
  year={1990},
  volume={58 9},
  pages={
          2760-9
        }
}
The nucleotide sequence of a Rickettsia rickettsii gene that encodes a high-molecular-mass surface antigen (190 kilodaltons), which elicits protective immunity, was determined. The 6,747-nucleotide gene coded for a 2,249-amino-acid protein with a calculated molecular weight of 224,321. A 3.8-kilobase PstI fragment proximal to the 5' end of the gene was found to consist of 13 highly related tandem repeats which constituted over 40% of the coding region. The repeated sequences could be divided… CONTINUE READING

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