A protective function for interleukin 17A in T cell–mediated intestinal inflammation

  title={A protective function for interleukin 17A in T cell–mediated intestinal inflammation},
  author={William K O'Connor and Masahito Kamanaka and Carmen J Booth and Terrence C. Town and Susumu Nakae and Yoichiro Iwakura and Jay K Kolls and Richard A Flavell},
  journal={Nature Immunology},
Interleukin 23 (IL-23) and IL-17 have been linked to the pathogenesis of several chronic inflammatory disorders, including inflammatory bowel disease. Yet as an important function for IL-23 is emerging, the function of IL-17 in inflammatory bowel disease remains unclear. Here we demonstrate IL-17A-mediated protection in the CD45RBhi transfer model of colitis. An accelerated wasting disease elicited by T cells deficient in IL-17A correlated with higher expression of genes encoding T helper type… CONTINUE READING
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