A protective effect of early pregnancy factor on experimental autoimmune encephalomyelitis induced in Lewis rats by inoculation with myelin basic protein.

@article{Harness2003APE,
  title={A protective effect of early pregnancy factor on experimental autoimmune encephalomyelitis induced in Lewis rats by inoculation with myelin basic protein.},
  author={Jacqueline Harness and Alice C. Cavanagh and Halle Morton and Pamela A. McCombe},
  journal={Journal of the neurological sciences},
  year={2003},
  volume={216 1},
  pages={33-41}
}
Experimental autoimmune encephalomyelitis (EAE) is an organ-specific autoimmune disease characterised by inflammation and demyelination of the central nervous system and is the best available animal model of multiple sclerosis (MS). Since previous studies have shown that EAE is less severe or is delayed in onset during pregnancy and that administration of the pregnancy hormone early pregnancy factor (EPF) down-regulates EAE, experiments in the present study were designed to explore further the… CONTINUE READING

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