A proteasome inhibitor reduces concurrent, sequential, and long-term IL-1 beta- and TNF-alpha-induced ECAM expression and adhesion.

@article{Dagia2003API,
  title={A proteasome inhibitor reduces concurrent, sequential, and long-term IL-1 beta- and TNF-alpha-induced ECAM expression and adhesion.},
  author={Nilesh M. Dagia and Douglas J. Goetz},
  journal={American journal of physiology. Cell physiology},
  year={2003},
  volume={285 4},
  pages={
          C813-22
        }
}
A promising approach for reducing aberrant leukocyte-endothelial adhesion during pathological inflammation is to inhibit endothelial cell adhesion molecule (ECAM) expression at the transcription level. Several compounds have been shown to decrease cytokine-induced upregulation of ECAMs primarily by modulating the activity of transcription factors [e.g., nuclear factor-kappa B (NF-kappa B)]. The majority of the in vitro studies have focused on the effect of transcription inhibitors on… CONTINUE READING

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  • American journal of physiology. Cell physiology
  • 2005
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