A proteasome inhibitor effectively prevents mouse heart allograft rejection.

@article{Luo2001API,
  title={A proteasome inhibitor effectively prevents mouse heart allograft rejection.},
  author={Hui Yan Luo and Yulian Wu and Shijie Qi and Xiaoxiao Wan and Huifang Chen and Jiang-ping Wu},
  journal={Transplantation},
  year={2001},
  volume={72 2},
  pages={196-202}
}
BACKGROUND We have previously demonstrated in vitro that proteasome inhibitors could suppress proliferation and induce apoptosis of activated T cells. This finding suggests that such inhibitors could be used as a novel category of immunosuppressants in blocking allograft rejection. METHODS The proteasome inhibitor dipeptide boronic acid (DPBA) was tested in vitro for its inhibitory effect on mouse T-cell proliferation and lymphokine secretion. DPBA was also used in vivo to treat mouse… CONTINUE READING

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