A protease-resistant form of insulin-like growth factor (IGF) binding protein 4 inhibits IGF-1 actions.

@article{Rees1998APF,
  title={A protease-resistant form of insulin-like growth factor (IGF) binding protein 4 inhibits IGF-1 actions.},
  author={Catherine E. D. Rees and DavidR. Clemmons and Gail D Horvitz and Jane Badley Clarke and Walker H. Busby},
  journal={Endocrinology},
  year={1998},
  volume={139 10},
  pages={
          4182-8
        }
}
Smooth muscle cells (SMC) secrete a serine protease that cleaves insulin-like growth factor (IGF) binding protein (IGFBP)-4 into fragments that have low affinity for IGF-1. When IGFBP-4 is added to monolayer cultures of cell types that do not secrete this protease, IGF-1 stimulation of DNA synthesis is significantly inhibited. In contrast, if cell types that secrete this protease are used, IGFBP-4 is a much less potent inhibitor. These studies were conducted to determine whether proteolysis of… CONTINUE READING

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