A protease-independent function for SPPL3 in NFAT activation.

  title={A protease-independent function for SPPL3 in NFAT activation.},
  author={Stefanie L Makowski and Zhaoquan Wang and Joel L Pomerantz},
  journal={Molecular and cellular biology},
  volume={35 2},
The signal peptide peptidase (SPP)-related intramembrane aspartyl proteases are a homologous group of polytopic membrane proteins, some of which function in innate or adaptive immunity by cleaving proteins involved in antigen presentation or intracellular signaling. Signal peptide peptidase-like 3 (SPPL3) is a poorly characterized endoplasmic reticulum (ER)-localized member of this family, with no validated cellular substrates. We report here the isolation of SPPL3 in a screen for activators of… CONTINUE READING
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