A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression.

@article{Majumder2008API,
  title={A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression.},
  author={Pradip K. Majumder and Chiara Grisanzio and Fionnuala O'connell and Marc I. Rosen Barry and Joseph M Brito and Qing Xu and Isil Guney and Raanan Berger and Paula Herman and Rachel E Bikoff and Giuseppe Fedele and Won-Ki Baek and Shunyou Wang and Katharine Ellwood-Yen and Hong Wu and Charles L Sawyers and Sabina Signoretti and William C. Hahn and Massimo F. Loda and William R Sellers},
  journal={Cancer cell},
  year={2008},
  volume={14 2},
  pages={146-55}
}
Transgenic expression of activated AKT1 in the murine prostate induces prostatic intraepithelial neoplasia (PIN) that does not progress to invasive prostate cancer (CaP). In luminal epithelial cells of Akt-driven PIN, we show the concomitant induction of p27(Kip1) and senescence. Genetic ablation of p27(Kip1) led to downregulation of senescence markers and progression to cancer. In humans, p27(Kip1) and senescence markers were elevated in PIN not associated with CaP but were decreased or absent… CONTINUE READING