A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding

  title={A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding},
  author={Qilai Huang and Thomas Whitington and Ping Gao and Johan Lindberg and Yuehong Yang and Jielin Sun and Marja-Riitta V{\"a}is{\"a}nen and Robert Szulkin and Matti Annala and Jian Yan and Lars Egevad and Kai Zhang and Ruizhu Lin and Arttu Jolma and Matti Nykter and Aki Manninen and Fredrik Wiklund and Markku H Vaarala and Tapio Visakorpi and Jianfeng Xu and Jussi Taipale and Gong-Hong Wei},
  journal={Nature Genetics},
Genome-wide association studies have identified thousands of SNPs associated with predisposition to various diseases, including prostate cancer. However, the mechanistic roles of these SNPs remain poorly defined, particularly for noncoding polymorphisms. Here we find that the prostate cancer risk-associated SNP rs339331 at 6q22 lies within a functional HOXB13-binding site. The risk-associated T allele at rs339331 increases binding of HOXB13 to a transcriptional enhancer, conferring allele… CONTINUE READING
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