A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

@article{Kliewer1995APJ,
  title={A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation},
  author={Steven A. Kliewer and James M. Lenhard and Timothy M Willson and Inder Patel and David C. Morris and J{\"u}rgen M. Lehmann},
  journal={Cell},
  year={1995},
  volume={83},
  pages={813-819}
}
Prostaglandins (PGs) of the J2 series form in vivo and exert effects on a variety of biological processes. While most of PGs mediate their effects through G protein-coupled receptors, the mechanism of action for the J2 series of PGs remains unclear. Here, we report the PGJ2 and its derivatives are efficacious activators of peroxisome proliferator-activated receptors alpha and gamma (PPAR alpha and PPAR gamma, respectively), orphan nuclear receptors implicated in lipid homeostasis and adipocyte… CONTINUE READING
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