A prostaglandin E2 receptor subtype EP1 receptor antagonist (ONO-8711) reduces hyperalgesia, allodynia, and c-fos gene expression in rats with chronic nerve constriction.

@article{Kawahara2001APE,
  title={A prostaglandin E2 receptor subtype EP1 receptor antagonist (ONO-8711) reduces hyperalgesia, allodynia, and c-fos gene expression in rats with chronic nerve constriction.},
  author={Hidero Kawahara and Atsuhiro Sakamoto and Shinhiro Takeda and Hidetaka Onodera and Junko Imaki and Ryoichi Ogawa},
  journal={Anesthesia and analgesia},
  year={2001},
  volume={93 4},
  pages={
          1012-7
        }
}
UNLABELLED Chronic constriction injury (CCI) of the sciatic nerve in rats induces persistent mechanical hyperalgesia and allodynia. CCI is widely known as a model of neuropathic pain, and many studies using this model have been reported. Recently, c-fos has been used as a neural marker of pain, and various studies have assessed the relationship between hyperalgesia and c-fos expression in the lumbar spinal cord. In this study, we examined the role of a prostaglandin E2 receptor subtype EP1… CONTINUE READING

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