A prospective trial of ionic vs nonionic contrast agents in routine clinical practice: comparison of adverse effects.

@article{Wolf1989APT,
  title={A prospective trial of ionic vs nonionic contrast agents in routine clinical practice: comparison of adverse effects.},
  author={Gerald L. Wolf and Ronald L. Arenson and Anna Cross},
  journal={AJR. American journal of roentgenology},
  year={1989},
  volume={152 5},
  pages={939-44}
}
A multicenter study of adverse effects of ionic and nonionic contrast agents was conducted in three similar time periods. In 1985, before approval of the nonionic contrast agents by the Food and Drug Administration, 6006 consecutive patients received iv ionic agents for urography or CT. After approval of the nonionic agents, 7170 consecutive patients referred for the same examinations were studied. The two groups of patients were significantly different, but the differences were small and did… CONTINUE READING

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