A prospective study of the association between the human humoral immune response to Plasmodium falciparum blood stage antigen gp190 and control of malarial infections.

@article{Tolle1993APS,
  title={A prospective study of the association between the human humoral immune response to Plasmodium falciparum blood stage antigen gp190 and control of malarial infections.},
  author={Ralf Tolle and K Fr{\"u}h and Ogobara K. Doumbo and Ousmane Koita and Mohamed N'diaye and Alain Fischer and Klaus Dietz and Hermann Bujard},
  journal={Infection and immunity},
  year={1993},
  volume={61 1},
  pages={40-7}
}
The human humoral immune response to the Plasmodium falciparum merozoite surface antigen gp190 was analyzed to determine the rate of reinfection by the parasite and the ability to control parasite density. The prospective study was carried out in a West African village where malaria is hyperendemic. No correlation between the antibody titers and protection against infection was observed within the group of children. Positive and negative associations of antibody specificities with protection… CONTINUE READING