A prospective study of maternal anti-HPA 1a antibody level as a potential predictor of alloimmune thrombocytopenia in the newborn.

@article{Killie2008APS,
  title={A prospective study of maternal anti-HPA 1a antibody level as a potential predictor of alloimmune thrombocytopenia in the newborn.},
  author={Mette Kjaer Killie and Anne Husebekk and Jens Kjeldsen-Kragh and Bj\orn R Skogen},
  journal={Haematologica},
  year={2008},
  volume={93 6},
  pages={870-7}
}
BACKGROUND Neonatal alloimmune thrombocytopenia is most commonly due to transplacental passage of maternal anti-HPA 1a antibodies. A prospective study was carried out to evaluate the pattern and quantity of maternal anti-HPA 1a antibodies in order to predict the level of thrombocytopenia in the neonates. DESIGN AND METHODS A monoclonal antibody immobilization of platelet antigen assay was used to detect antibodies in maternal samples from 1,990 HPA 1bb women. HLA DRB3*0101 typing was… CONTINUE READING

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