A prospective study of cognitive function in children receiving whole-brain radiotherapy and chemotherapy: 2-year results.

@article{Packer1989APS,
  title={A prospective study of cognitive function in children receiving whole-brain radiotherapy and chemotherapy: 2-year results.},
  author={Roger J. Packer and Leslie N. Sutton and Tina Atkins and Jerilynn Radcliffe and Greta R. Bunin and G D'angio and Kathy R. Siegel and Lawrence Schut},
  journal={Journal of neurosurgery},
  year={1989},
  volume={70 5},
  pages={707-13}
}
As survival rates have risen for children with malignant primary brain tumors, so has the concern that many survivors have significant permanent cognitive deficits. Cranial irradiation (CRT) has been implicated as the major cause for cognitive dysfunction. To clarify the etiology, incidence, and severity of intellectual compromise in children with brain tumors after CRT, a prospective study was undertaken comparing the neuropsychological outcome in 18 consecutive children with malignant brain… CONTINUE READING
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